%0 Journal Article
%T MEK inhibition suppresses K-Ras wild-type cholangiocarcinoma in vitro and in vivo via inhibiting cell proliferation and modulating tumor microenvironment
%A Antonio Cigliano
%A Diego F. Calvisi
%A Ekihiro Seki
%A Jie Zhang
%A John Gordan
%A Kirsten Utpatel
%A Li Che
%A Matthias Evert
%A Meng Xu
%A Pan Wang
%A Runze Shang
%A Xiaosong Hu
%A Xin Chen
%A Xinhua Song
%A Yoon Mee Yang
%J Archive of "Cell Death & Disease".
%D 2019
%R 10.1038/s41419-019-1389-4
%X a, b IC50 values calculated by quantifying the Crystal violet staining from SNU1196 (a) and OCUG (b) cell line treated for 3 days with the indicated doses of PD901 and MNL0128. c, d Combining PD901 with MNL0128 (concentration of IC50) resulted in reduced cell viability of SNU1196 (c) and OCUG (d) compared with PD901 or MNL0128 single treatment. Abbreviations: Combo, combined PD9018/MNL012 treatment. Tukey¨CKramer test: at least P£¿<£¿0.005 a, vs DMEM b, vs MLN0128; c, vs PD90
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370758/