%0 Journal Article
%T CUL1 promotes breast cancer metastasis through regulating EZH2-induced the autocrine expression of the cytokines CXCL8 and IL11
%A Hong-Mei Yong
%A Jin Bai
%A Jun Song
%A Jun-Nian Zheng
%A Meng Zhang
%A Ping-Fu Hou
%A Yan-Su Chen
%A Ye-Fei Huang
%A Zhe Zhang
%J Archive of "Cell Death & Disease".
%D 2019
%R 10.1038/s41419-018-1258-6
%X a The CUL1 protein expression in human normal human mammary epithelial cell line MCF10A and breast cancer cell lines were determined by western blotting. b MCF10A cells were transiently transfected with CUL1 overexpression (PCDNA3.1-CUL1) and vector control (PCDNA3.1) plasmids. c The migration and invasion of MCF10A cells with CUL1 overexpression and vector control. d The number of cell migration and invasion per field was counted in five random fields (n£¿=£¿3/group). e Western blots of EMT-related markers E-cadherin, ¦Â-catenin, N-cadherin, Vimentin, and Fibronectin in MCF10A with CUL1 overexpression and vector control. f Relative mRNA expression levels of EMT markers (normalization to GAPDH) in MCF10A cells with CUL1 overexpression and vector control. Data are presented as means£¿¡À£¿standard deviations. *P£¿<£¿0.05, **P£¿<£¿0.001 (Student¡¯s t-test
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315038/