%0 Journal Article
%T The interplay between extracellular matrix remodelling and kinase signalling in cancer progression and metastasis
%A Joanna N. Skhinas
%A Thomas R. Cox
%J Archive of "Cell Adhesion & Migration".
%D 2018
%R 10.1080/19336918.2017.1405208
%X The extracellular matrix (ECM) is a master regulator of cellular phenotype and behaviour. It plays a crucial role in both normal tissue homeostasis and complex diseases such as cancer. The interplay between the intrinsic factors of cancer cells themselves, including their genotype and signalling networks; and the extrinsic factors of the tumour stroma, such as the ECM and ECM remodelling; together determine the fate and behaviour of cancer cells. As a consequence, tumour progression, metastatic spread and response to therapy are ultimately controlled by ECM-driven fine-tuning of intracellular kinase signalling. The ability to target and uncouple this interaction presents an emerging and promising potential in the treatment of cancer
%K Extracellular Matrix
%K Remodelling
%K Kinase Signalling
%K Cancer
%K Metastasis
%K Lysyl Oxidase
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363022/