%0 Journal Article
%T Structures of the human spliceosomes before and after release of the ligated exon
%A Chuangye Yan
%A Dongliang Liu
%A Jianlin Lei
%A Wenyu Zhang
%A Xiaofeng Zhang
%A Xiechao Zhan
%A Yigong Shi
%J Archive of "Cell Research".
%D 2019
%R 10.1038/s41422-019-0143-x
%X Cryo-EM structures of the human post-catalytic spliceosome (P complex) and the human intron lariat spliceosome (ILS complex). a Structure of the human spliceosomal P complex at an average resolution of 3.0£¿£¿. Two perpendicular views are shown. Components of the P complex are color-coded and tabulated below the structure. NTC: NineTeen complex; NTR: NTC-related complex. b Structure of the human ILS complex 1 (ILS1) at an average resolution of 2.91£¿£¿. The ATPase/helicase Prp43 is yet to be loaded in the ILS1 complex. c Structure of the human ILS complex 2 (ILS2) at an average resolution of 2.86£¿£¿. Prp43 is present in the ILS2 complex, ready to disassemble the spliceosom
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461851/