%0 Journal Article
%T Macrophages exposed to HIV viral protein disrupt lung epithelial cell integrity and mitochondrial bioenergetics via exosomal microRNA shuttling
%A David M. Guidot
%A F. Eun-Hyung Lee
%A Jessica R. Petree
%A Khalid Salaita
%A Ruxana T. Sadikot
%A Xian Fan
%A Zhihong Yuan
%J Archive of "Cell Death & Disease".
%D 2019
%R 10.1038/s41419-019-1803-y
%X Human MDMs were infected with HIV-1 for 8 days. MiRNAs were extracted and analyzed via qRT-PCR and normalized to U6 gene. a miR-155; b miR-23a; c miR-27a; d miR-21. Student¡¯s test, *p£¿<£¿0.05. THP-1-derived macrophages and human MDMs were treated with recombinant HIV viral protein Tat (100£¿ng/ml) and gp120 (100£¿ng/ml), respectively. Twenty-four hours later, expression levels of miRNAs were analyzed by qRT-PCR and normalized to U6 gene. e miR-155; f miR-23a; g miR-27a; h miR-21. Student¡¯s test, *p£¿<£¿0.0
%K Monocytes and macrophages
%K Monocytes and macrophages
%K HIV infections
%K HIV infections
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6675785/