%0 Journal Article
%T Inhibition of the BET family reduces its new target gene IDO1 expression and the production of l-kynurenine
%A Bing Xiong
%A Chang-Qing Tian
%A Hua-Dong Chen
%A Jian-Ping Hu
%A Jing-Kang Shen
%A Lin Chen
%A Xia-Juan Huan
%A Ying-Qing Wang
%A Ze-Hong Miao
%J Archive of "Cell Death & Disease".
%D 2019
%R 10.1038/s41419-019-1793-9
%X a The number of the significantly differentially expressed genes (fold change£¿>£¿2, p£¿<£¿0.05) in Ty-82 cells treated with 1£¿¦ÌM compound 9 for 12 or 24£¿h. b Genes of the differentially downregulated expression in the compound 9-treated Ty-82 cells were plotted as the Venn diagram to display the commonly downregulated genes. c Heatmaps of 70 common genes of the differentially downregulated expression in Ty-82 cells treated with compound 9 for 0, 12, or 24£¿h, ranked (1¨C70) by fold change from big to small after 24-h treatments. Also see Supplementary Table S1¨C3. d¨Cg Ty-82 cells were treated with the BET inhibitor ABBV-075 at the indicated concentrations for the indicated time. The mRNA (d, e) and protein (f, g) levels of IDO1 were determined by RT-qPCR and western blotting, respectively. Data were from three independent experiments, and if applicable, were expressed as mean£¿¡À£¿SD (error bar); *p£¿<£¿0.05; **p < 0.01; ***p < 0.00
%K Cancer immunotherapy
%K Immunosuppression
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642217/