%0 Journal Article
%T The natural compound neobractatin inhibits tumor metastasis by upregulating the RNA-binding-protein MBNL2
%A Hongxi Xu
%A Jing Wang
%A Juan Zhang
%A Li Zhang
%A Man Wu
%A Naihan Xu
%A Wenwei Fu
%A Yuanzhi Lao
%A Zhaoqing Zheng
%A Zhili Zhao
%J Archive of "Cell Death & Disease".
%D 2019
%R 10.1038/s41419-019-1789-5
%X a Chemical structure of NBT. b Cell viability assays. The MTT assay was used to examine the cell viability in the absence or presence of different doses of NBT for 24£¿h. c Wound healing assay. A scratch was made in monolayers of MDA-MB-231 and A549 cells, and the migration ability of the cells treated with or without different concentrations of NBT was monitored with an inverted microscope. d Cell migration measured by transwell assays. The cells were treated with different concentrations of NBT for 24£¿h, and migrated or invaded cells were fixed and stained with 0.1% crystal violet. e The summary of data for transwell migration assays. f Western blot asssay. MDA-MB-231 and A549 cells were treated with NBT (2.5£¿¦ÌM) for indicated time points. Data shown are mean£¿¡À£¿SD of three independent experiments. ***P£¿<£¿0.00
%K Breast cancer
%K Collective cell migration
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639345/