%0 Journal Article
%T F-box protein FBXO30 mediates retinoic acid receptor ¦Ã ubiquitination and regulates BMP signaling in neural tube defects
%A Dan Li
%A Jianxin Wu
%A Juan Yu
%A Pei Pei
%A Qin Zhang
%A Shan Wang
%A Ting Zhang
%A Xiaolu Xie
%A Xiyue Cheng
%J Archive of "Cell Death & Disease".
%D 2019
%R 10.1038/s41419-019-1783-y
%X a iTRAQ ratio of F-box family for control and NTD brain tissue smaples: control samples (C2, C3, and C7); NTD samples (N5, N6, and N10). b SiRNA-NC vs. siRNA-FBXO30 in NT2/D1 cells. The total RNA was analyzed using RNA-seq. A total of DEGs showing differential expression were identified in the APN-treatment group (P£¿<£¿0.05). c KEGG analysis of the DEGs in indicated groups. The £¿log10 p value of enrichment is shownon x-axis; the numbers represent the number of associated proteins for each term. d NT2/D1 cells were transfected with siRNA FBXO30. Expression of developmental pathway-related genes was analyzed by qPCR. All the above data are mean£¿¡À£¿SD. (n£¿=£¿3), *p£¿<£¿0.05, by Student¡¯s t tes
%K Developmental neurogenesis
%K Cellular neuroscience
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639381/