%0 Journal Article
%T Bariatric surgery and hypertension: implications and perspectives after the GATEWAY randomized trial
%A Albert Goday
%A David Benaiges
%A Elisenda Climent
%A Juan Pedro-Botet
%A Juana A. Flores-Le Roux
%J Archive of "Cardiovascular Diagnosis and Therapy".
%D 2019
%R 10.21037/cdt.2018.10.04
%X Obesity prevalence has presented an exponential increase in the last years, becoming a serious public health issue (1). Moreover, patients with an increased body mass index exhibit different comorbidities, including hypertension, which are tightly related to the high cardiovascular risk of this population (2). In the United States, half of the patients with hypertension display obesity. Moreover, a third of obese subjects have high blood pressure levels, compared to the 20% observed in subjects with a normal body mass index (3). Furthermore, the intervention strategy for hypertension in patients with obesity implies various challenges concerning the effect of the pharmacological treatment. In this respect, obesity leads to a resistance to antihypertensive medication together with disturbances in volume distribution and hepatic and renal clearance (4). This implies that patients with hypertension and obesity in general require a more ˇ°aggressiveˇ± antihypertensive treatment in order to achieve desirable blood pressure levels
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382659/