%0 Journal Article
%T Successful Treatment of Gastrosplenic Fistula Arising from Diffuse Large B-Cell Lymphoma with Chemotherapy: Two Case Reports
%A Akio Mori
%A Kencho Miyashita
%A Koh Izumiyama
%A Makoto Saito
%A Masanobu Morioka
%A Masanori Tanaka
%A Reiki Ogasawara
%A Shinpei Harada
%A Takeshi Kondo
%A Yosuke Miura
%J Archive of "Case Reports in Oncology".
%D 2019
%R 10.1159/000500505
%X Gastrosplenic fistula (GSF) is a rare condition arising from gastric or splenic lymphomas. Surgical resection is the most common treatment, as described in previous reports. We report two cases of GSF in diffuse large B-cell lymphoma (DLBCL) patients that were successfully treated with chemotherapy and irradiation without surgical resection. Case 1 was of a 63-year-old man who had primary gastric DLBCL with a large lesion outside the stomach wall, leading to a spontaneous fistula in the spleen. Case 2 was of a 59-year-old man who had primary splenic DLBCL, which proliferated and infiltrated directly into the stomach. In both cases, chemotherapy comprising rituximab + dose-adjusted EPOCH regimen (etoposide, prednisone, vincristine, cyclophosphamide and doxorubicin) was administered. Case 1 had significant bleeding from the lesion of the stomach during the treatment cycle; however, endoscopic hemostasis was achieved. Case 2 developed a fistula between the stomach and the spleen following therapeutic chemotherapy; however, no complications related to the fistula were observed thereafter. In both cases, irradiation was administered, and complete remission was achieved
%K Gastrosplenic fistula (GSF)
%K Diffuse large B-cell lymphoma (DLBCL)
%K Treatment
%K Chemotherapy
%K Irradiation
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547279/