%0 Journal Article
%T Concomitant Non-Small Cell Lung Cancer and Hairy Cell Leukemia in a Patient Harboring BRAF-V600E Mutation in Both Tissues: A Case Report
%A Aristoteles Giagounidis
%A Bernd Klosterhalfen
%A Felipe Crespo
%A Karl Axel Hartmann
%A Maria Mitsogianni
%A Nikolaos Mitsimponas
%A Sabine Haase
%J Archive of "Case Reports in Oncology".
%D 2018
%R 10.1159/000486640
%X The BRAF-V600E mutation has been established as a signature alteration occurring almost universally in hairy cell leukemia. Moreover, it can be detected in a small percentage of patients with non-small cell lung cancer. We report the case of a patient with a metastatic BRAF-V600E-mutated lung adenocarcinoma suffering from concomitant hairy cell leukemia. The identification of an identical BRAF mutation in both malignancies raises physiopathological considerations and might offer unique therapeutic strategies for this group of patients
%K BRAF-V600E mutation
%K Driver mutations
%K Non-small cell lung cancer
%K Lung adenocarcinoma
%K Hairy cell leukemia
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869534/