%0 Journal Article
%T The action of ¦Â-hydroxybutyrate on the growth, metabolism and global histone H3 acetylation of spontaneous mouse mammary tumours: evidence of a ¦Â-hydroxybutyrate paradox
%A Basetti Madhu
%A Davina J. Honess
%A John R. Griffiths
%A Loreta M. Rodrigues
%A Marion Stubbs
%A Santiago Uribe-Lewis
%J Archive of "Cancer & Metabolism".
%D 2017
%R 10.1186/s40170-017-0166-z
%X Ketone bodies have both metabolic and epigenetic roles in cancer. In several studies, they showed an anti-cancer effect via inhibition of histone deacetylases; however, other studies observed faster tumour growth. The related molecule butyrate also inhibits growth of some cancer cells and accelerates it in others. This ¡°butyrate paradox¡± is thought to be due to butyrate mediating histone acetylation and thus inhibiting cell proliferation in cancers that preferentially utilise glucose (the Warburg effect); whereas in cells that oxidise butyrate as a fuel, it fails to reach inhibitory concentrations and can stimulate growth
%K Ketone bodies
%K ¦Â-hydroxybutyrate
%K NEU/HER2 mammary tumours
%K Warburg effect
%K Histone acetylation
%K Magnetic Resonance Spectroscopy
%K Metabolites
%K Glycolysis
%K Oxidative phosphorylation
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331634/