%0 Journal Article
%T Pharmacokinetic Interactions between Valproic Acid and Lorazepam (PIVOtAL Study): A Review of Site-Specific Practices
%A Joane Y Tang
%A Mary H H Ensom
%A Tony K L Kiang
%J Archive of "The Canadian Journal of Hospital Pharmacy".
%D 2017
%X Coadministration of lorazepam and valproic acid is identified by tertiary references as causing a major drug interaction that requires therapy modification and dosage adjustments. The proposed mechanism involves inhibition of lorazepam glucuronidation via direct inhibition of uridine 5¡ä-diphosphate-glucuronosyltransferase enzymes by valproic acid. However, the clinical significance of this interaction is unclear
%K valproic acid
%K lorazepam
%K pharmacokinetics
%K drug-drug interaction
%K uridine 5¡ä-diphosphate-glucuronosyltransferases acide valpro£¿que
%K loraz¨¦pam
%K pharmacocin¨¦tique
%K interaction m¨¦dicament-m¨¦dicament
%K uridine 5¡ä-diphosphate glucuronosyltransf¨¦rases
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491192/