%0 Journal Article
%T Beneficial Treatment Management with Trifluridine/Tipiracil in a Patient with Metastatic Colorectal Cancer and Pronounced Hematological Event History during Previous Treatments
%A J¨¹rgen Hess
%A Volker Kaechele
%A Wolfgang Schneider-Kappus
%J Archive of "Case Reports in Oncology".
%D 2018
%R 10.1159/000486195
%X Trifluridine/tipiracil (FTD/TPI) significantly improves overall survival in patients with metastatic colorectal cancer (mCRC). The most common treatment-related event (grade ¡Ý3) was hematological toxicity. We here report long-term disease-stabilizing FTD/TPI treatment of an mCRC patient (KRAS wild-type, ECOG performance status 1 at baseline and at the end of FTD/TPI therapy) with multifocal synchronous metastases and a longstanding history of extensive hematological events during previous treatments. Finally, this 62-year-old male patient was treated for 10 months with FTD/TPI by consecutive alteration of treatment parameters: (i) initial daily dose reduction to 80 mg (72% of the recommended dose), (ii) 20 days dose delay, (iii) a second and later third dose reduction to 70 mg and 60 mg (about 64% and 55%, respectively, of the recommended dose), and (iv) 30 ¦Ìg per day of granulocyte colony-stimulating factor administration first for 3 days, and later for 5 days, for each treatment cycle
%K Colorectal cancer
%K Chemotherapy
%K Trifluridine/tipiracil
%K Dose reduction
%K Myelosuppression
%K Granulocyte colony-stimulating factor
%K Hemotoxicity
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836196/