%0 Journal Article
%T Successful Treatment of Nivolumab-Resistant Multiple In-Transit Melanomas with Ipilimumab and Topical Imiquimod
%A Akira Hashimoto
%A Akira Tsukada
%A Hisayuki Tono
%A Kayo Tanita
%A Sadanori Furudate
%A Setsuya Aiba
%A Taku Fujimura
%A Yota Sato
%A Yumi Kambayashi
%J Archive of "Case Reports in Oncology".
%D 2018
%R 10.1159/000485612
%X Simultaneous or sequential, planned administration of ipilimumab could significantly enhance the antitumor effects of nivolumab in advanced melanoma patients. On the other hand, the efficacy of ipilimumab for nivolumab-resistant advanced melanoma is extremely poor. Therefore, additional supportive therapy for anti-PD-1 antibody therapy-resistant advanced melanoma has been widely investigated. In this report, we describe a case of multiple in-transit melanomas developing in a nivolumab-resistant patient successfully treated with ipilimumab in combination with imiquimod. Our present case suggested a possible therapy for nivolumab-resistant multiple in-transit melanomas using ipilimumab in combination with topical imiquimod
%K Nivolumab-resistant melanoma
%K Ipilimumab
%K Imiquimod
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836202/