%0 Journal Article
%T The established and the predicted roles of dynein light chain in the regulation of mitochondrial apoptosis
%A Arnim Weber
%A Georg H£¿cker
%A Prafull Kumar Singh
%J Archive of "Cell Cycle".
%D 2018
%R 10.1080/15384101.2018.1464851
%X The mitochondrial pathway of apoptosis is regulated by the interplay between the members of Bcl-2 family. Within this family, BH3-only proteins are the sensors of apoptotic stimuli and can trigger apoptosis either by inhibiting the anti-apoptotic Bcl-2-family proteins or by directly activating the effectors Bax and Bak. An expanding body of research suggests that a number of non-Bcl-2 proteins can also interact with Bcl-2 proteins and contribute to the decision of cell fate. Dynein light chain (LC8, DYNLL or DLC), a hub protein and a dimerizing engine has been proposed to regulate the pro-apoptotic activity of two BH3-only proteins, Bim and Bmf. Our recent work has provided insight into the mechanisms through which DLC1 (DYNLL1) modulates Bim activity. Here we discuss the present day understanding of Bim-DLC interaction and endeavor to evaluate this interaction in the light of information from studies of DLC with other binding partners
%K Apoptosis
%K dynein light chain (DLC)
%K Bim
%K Bmf
%K intrinsically disordered protein
%K nanny protein
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110606/