%0 Journal Article
%T Aquaporin 3 maintains the stemness of CD133+ hepatocellular carcinoma cells by activating STAT3
%A Gang Wu
%A Qi Zhang
%A Shaolin Xu
%A Tianlong Wang
%A Xueyan Fu
%A Yawei Wang
%A Ye Yang
%J Archive of "Cell Death & Disease".
%D 2019
%R 10.1038/s41419-019-1712-0
%X a The expression levels of AQP3 mRNA in 37 cases HCC tumor tissues and the corresponding normal tissues according to qRT-PCR. b The average mRNA expression levels (2£¿¦¤ct) of AQP3 in 37 HCC tumor tissues and the corresponding normal tissues according to qRT-PCR. c The expression levels of AQP3 protein in 10 cases HCC tumor tissues and the corresponding normal tissues according to western blotting. d According to IHC in 120 HCC paraffin section specimens, AQP3 protein appeared to be expressed in the cytomembrane of tumor cells. e AQP3 was high expressed in 7 HCC cell lines (HUH7, HCCLM3, SMMC7721, HepG2, bel7402, PLC/PRF/5, Hep3B) than the normal liver cell lines (L02). f According to IHC in 120 HCC paraffin section specimens, the overall survival in patients with high AQP3 expression was significantly lower than in patients with low AQP3 expression (P£¿<£¿0.01, KM survival curve
%K Cancer stem cells
%K Outcomes research
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6565673/