%0 Journal Article
%T NETO2 promotes invasion and metastasis of gastric cancer cells via activation of PI3K/Akt/NF-¦ÊB/Snail axis and predicts outcome of the patients
%A Bo Tang
%A Feng Qian
%A Jia-jia Liu
%A Jun-yan Fan
%A Jun-yan Liu
%A Lei Jiang
%A Pei-wu Yu
%A Tao He
%A Xian-hui Xu
%A Yan Shi
%A Yan Wang
%A Yong-liang Zhao
%A You-hong Cui
%J Archive of "Cell Death & Disease".
%D 2019
%R 10.1038/s41419-019-1388-5
%X a Representative immunohistochemical staining (IHC) images of NETO2 in adjacent normal tissue, gastric cancer tissues with different invasion depth and metastatic lymph node. Scale bar£¿=£¿50£¿¦Ìm. b The IHC score of NETO2 in gastric cancer tissues was significantly higher than that in adjacent normal tissues. c High expression of NETO2 was more frequent in gastric cancer tissues than in adjacent normal tissues. d Data in GEO {"type":"entrez-geo","attrs":{"text":"GSE29272","term_id":"29272"}}GSE29272 showed higher mRNA level of NETO2 in gastric cancer tissues compared to adjacent normal tissues. e Data in TCGA database showed higher mRNA level of NETO2 in gastric cancer tissues compared to adjacent normal tissues. f mRNA levels of NETO2 were higher in 20 fresh surgical gastric tumor specimens (t) than that in paired adjacent normal tissues (n). g NETO2 protein levels were higher in eight fresh surgical gastric cancer (t) tissues than that in adjacent normal (n) tissues. h Kaplan¨CMeier estimation indicated significantly lower overall and disease-free survival rates in patients with NETO2high gastric cancer than that in NETO2low patients. i Data in KMPLOT database showed that NETO2high patients had significantly lower overall and disease-free survival rates than that in NETO2low patients. j Data in TCGA database showed that NETO2high patients had significantly lower overall survival rate than that in NETO2low patients. *p£¿<£¿0.05, ***p£¿<£¿0.00
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377647/