%0 Journal Article
%T LncRNA H19-elevated LIN28B promotes lung cancer progression through sequestering miR-196b
%A Bingdi Yan
%A Dan Wang
%A Jin Ren
%A Jinling Fu
%A Rong Gao
%A Tiangang Ma
%A Zhe An
%J Archive of "Cell Cycle".
%D 2018
%R 10.1080/15384101.2018.1482137
%X LncRNA H19 is involved in the development of multiple cancers. Here, we firstly provide new evidence that H19 can induce LIN28B, a conserved RNA binding protein, to accelerate lung cancer growth through sponging miR-196b. Abundance in LIN28B was observed in clinical lung cancer samples. A positive link was observed between H19 and LIN28B in clinical lung cancer samples. In lung cancer cells, H19 was capable of increasing LIN28B expression. Mechanistically, miR-196b directly targeted LIN28B to inhibit LIN28B expression. H19 was capable of promoting LIN28B expression through sequestering miR-196b. Functionally, H19-increased LIN28B conferred the cell proliferation of lung cancer. Our finding indicates that H19 depresses miR-196b to elevate LIN28B, resulting in accelerating cell proliferation in lung cancer
%K H19
%K LIN28B
%K miR-196b
%K growth
%K lung cancer
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110585/