%0 Journal Article
%T Hemi-methylated CpG sites connect Dnmt1-knockdown-induced and Tet1-induced DNA demethylation during somatic cell reprogramming
%A Dajiang Qin
%A Duanqing Pei
%A Fuhui Wang
%A Hao Sun
%A Hongshen Pang
%A Hui Zheng
%A Jinlong Chen
%A Lining Liang
%A Mengdan Zhang
%A Songwei He
%A Xiao Yang
%A Xiaofen Huang
%A Yingying Li
%A Yixin Zhang
%A Yuan Li
%J Archive of "Cell Discovery".
%D 2019
%R 10.1038/s41421-018-0074-6
%X a Schematic illustration of the three experimental systems used in the current studies. b¨Cd The influences of sh-Dnmt1 and Tet1 on the methylation levels of CpG sites near TSS (£¿1.5£¿~£¿+£¿2.0£¿kb) (b), methylation levels of all protein-coding genes (c), and iPSC generation (d) were summarized. e¨Cj CpG sites (near TSS, £¿1.5£¿~£¿+£¿2.0£¿kb) and genes with a larger demethylation than average were further selected. The overlapping targets of the two types of DNA demethylation were summarized in e¨Ch. In addition, the correlations between demethylation induced by sh-Dnmt1 and Tet1 were listed in f and i. Consistently demethylated CpG sites near TSS (approximately 82,000, g) and genes (1680, j) were summarized by overlapping the results shown in e and h. k¨Cm Dnmt1 and sh-Dnmt1 were over-expressed with Tet1. The overall methylation levels of the CpG sites near TSS (£¿1.5£¿~£¿+£¿2.0£¿kb) (k), overall methylation levels of all protein-coding genes (l), and iPSC generation (m) were summarize
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370818/