%0 Journal Article
%T Turning an old GADDget into a troublemaker
%A Daniel D¡¯Andrea
%A Daniela Verzella
%A Daria Capece
%A Federica Begalli
%A Francesca Zazzeroni
%A Guido Franzoso
%A Jason Bennett
%A Laura Tornatore
%J Archive of "Cell Death and Differentiation".
%D 2018
%R 10.1038/s41418-018-0087-6
%X Schematic representation of the dual functions of GADD45¦Â in oncogenesis. GADD45¦Â mediates its distinct oncogenic functions through separate tissue-specific mechanisms, which promote cancer cell survival by inhibiting sustained MKK7/JNK activation (left) and suppress TME-based inflammation, pro-inflammatory TAM activation and CD8+ T-cell recruitment into tumours by attenuating p38 signalling in myeloid cells (right). Also shown is how GADD45¦Â-targeting therapeutic agents could provide an effective means of countering oncogenesis by promoting TME-based inflammation and adaptive anti-tumour immune responses (right) and, at the same time, inducing malignant cell apoptosis (left), thus affording a dual clinical benefit
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864189/