%0 Journal Article
%T Nucleophagy: from homeostasis to disease
%A Margarita-Elena Papandreou
%A Nektarios Tavernarakis
%J Archive of "Cell Death and Differentiation".
%D 2019
%R 10.1038/s41418-018-0266-5
%X Types of autophagy. Macroautophagy involves the formation of the autophagosome. Initiation occurs with Unc-51-like kinase 1 activation and concomitant triggering of the phosphatidyl-inositol-3-kinase complex, Vps15/Vps34/Beclin 1 complex. In turn, two ubiquitin conjugation systems, ATG5/ATG7/ATG12 and LC3, are required for autophagosome formation and maturation. Autophagosome¨Clysosome fusion allows for degradation of autophagic substrates, such as p62. Microautophagy happens with direct interaction of the substrate and the lysosome. Chaperone-mediated autophagy requires chaperone targeting of specific proteins with the pentapeptide motif KFERQ to the lysosome-associated membrane protein LAMP-2
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460388/