%0 Journal Article
%T The Functional Role of Prostate Cancer Metastasis-related Micro-RNAs
%A ALEXANDRA EPP
%A FABIAN BIRZELE
%A ULRICH BRINKMANN
%A ULRICH H WEIDLE
%J Archive of "Cancer Genomics & Proteomics".
%D 2019
%R 10.21873/cgp.20108
%X The mortality of patients with hormone-resistant prostate cancer can be ascribed to a large degree to metastasis to distant organs, predominantly to the bones. In this review, we discuss the contribution of micro-RNAs (miRs) to the metastatic process of prostate cancer. The criteria for selection of miRs for this review were the availability of preclinical in vivo metastasis-related data in conjunction with prognostic clinical data. Depending on their function in the metastatic process, the corresponding miRs are up- or down-regulated in prostate cancer tissues when compared to matching normal tissues. Up-regulated miRs preferentially target suppressors of cytokine signaling or tumor suppressor-related genes and metastasis-inhibitory transcription factors. Down-regulated miRs promote epithelial¨Cmesenchymal transition or mesenchymal¨Cepithelial transition and diverse pro-metastatic signaling pathways. Some of the discussed miRs exert their function by simultaneously targeting epigenetic pathways as well as cell-cycle-related, anti-apoptotic and signaling-promoting targets. Finally, we discuss potential therapeutic options for the treatment of prostate cancer-related metastases by substitution or inhibition of miRs
%K In vivo metastasis models
%K interference with signaling networks
%K miR substitution and inhibition
%K prognostic aspects
%K prometastatic pathways
%K target validation
%K review
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348398/