%0 Journal Article
%T Wnt3a ligand facilitates autophagy in hippocampal neurons by modulating a novel GSK-3¦Â-AMPK axis
%A Juan A. Godoy
%A Juvenal A. R¨ªos
%A Nibaldo C. Inestrosa
%J Archive of "Cell Communication and Signaling : CCS".
%D 2018
%R 10.1186/s12964-018-0227-0
%X Wnt3a ligand modulates AMPK activity in hippocampal neurons. a Wnt3a ligand significantly increases AMPK phosphorylation at Thr172 between 15 and 60 min of treatment. b GSK-3¦Â shows significant inhibition (phosphorylation at Ser9) from 5 to 15 min of treatment with Wnt3a ligand. c ¦Â-catenin did not accumulate in neurons over the same time course. d Graphic showing kinetic summary of AMPK activation and GSK-3¦Â inhibition. The data are expressed as the mean£¿¡À£¿S.E.M. of n£¿=£¿3 independent experiments, *p£¿<£¿0.05, **p£¿<£¿0,001, n.s, non-significan
%K Neuron
%K Wnt signaling
%K AMPK
%K Autophagy
%K Metabolism
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896060/