%0 Journal Article
%T Notch signaling triggered via the ligand DLL4 impedes M2 macrophage differentiation and promotes their apoptosis
%A B¨¦atrice Charreau
%A Nathalie G¨¦rard
%A Sylvain Pagie
%J Archive of "Cell Communication and Signaling : CCS".
%D 2018
%R 10.1186/s12964-017-0214-x
%X DLL4 impairs M2 macrophage polarization. a Phenotype analysis of macrophages before (M0) and after polarization in M1 or M2 macrophages for 24 h with LPS and IFN-¦Ã or IL-4, respectively (n£¿=£¿5). b Phenotype analysis of M0, M1 and M2 macrophages polarized during 24 h with (+rhDLL4) or without (£¿rhDLL4) coated rhDLL4 (n£¿=£¿5). Data are expressed as fold increases ¡À SD from 5 independant experiments. M1-specific and M2-specific makers are indicated. Mann-Whitney test was used for statistical analysis of the results (*p£¿<£¿0.05 and ** if p£¿<£¿0.01
%K Notch pathway
%K Notch1
%K DLL4
%K Il-4
%K M2 macrophage
%K Macrophage
%K Polarization
%K JAK/stat
%K Apoptosis
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764024/