%0 Journal Article
%T High-density lipoproteins attenuate high glucose-impaired endothelial cell signaling and functions: potential implications for improved vascular repair in diabetes
%A Christina A. Bursill
%A My-Ngan Duong
%A Peter J. Psaltis
%A Stephen J. Nicholls
%A Xing Chen
%J Archive of "Cardiovascular Diabetology".
%D 2017
%R 10.1186/s12933-017-0605-8
%X HDL attenuates dextrose-induced inhibition of HUVEC proliferation. a Cell proliferation was determined after cells were incubated with dextrose (5.7, 20 and 40 mM) or dextrose plus HDL (80 ¦Ìg/mL) for 96 h using BrdU incorporation. 2.5% FBS (control) and 15% FBS (positive control) treatments were also included. b Protein levels of PCNA were determined in HUVEC lysates incubated with dextrose (5.7, 20 and 40 mM) or dextrose plus HDL (80 ¦Ìg/mL) for 72 h using Western blotting. ¦Â-Actin was used as the protein loading control. Data shown are the mean ¡À SEM of results from three independent experiments. #p < 0.05 relative to the respective control (cells in MCDB medium containing 2.5% FBS). *p < 0.05 relative to the dextrose only treatments at the same concentratio
%K HDL
%K Hyperglycaemia
%K Endothelial cells
%K Atherosclerosis
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622442/