%0 Journal Article
%T The effects of basal insulin peglispro vs. insulin glargine on lipoprotein particles by NMR and liver fat content by MRI in patients with diabetes
%A Bertrand Cariou
%A Byron J. Hoogwerf
%A Caryl J. Antalis
%A James D. Otvos
%A Margery A. Connelly
%A Shuyu Zhang
%A Tibor Ivanyi
%A Trevor J. Orchard
%J Archive of "Cardiovascular Diabetology".
%D 2017
%R 10.1186/s12933-017-0555-1
%X In Phase 2/3 studies of basal insulin peglispro (BIL) compared to insulin glargine, patients with type 1 or type 2 diabetes previously treated with insulin and randomized to BIL had an increase in serum triglycerides (TGs). To further understand lipoprotein changes, a lipid substudy which included liver fat content was designed to assess relationships among the measured variables for each diabetes cohort and compare the hepato-preferential insulin BIL to glargine
%K Diabetes
%K Basal insulin peglispro
%K Insulin glargine
%K Lipoproteins
%K NMR
%K Apolipoproteins
%K Liver fat
%K MRI
%K Adiponectin
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461740/