%0 Journal Article
%T The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) activator dh404 protects against diabetes-induced endothelial dysfunction
%A Arpeeta Sharma
%A Judy B. de Haan
%A Keith W. Ward
%A Luddwi Rizky
%A Mitchel Tate
%A Nada Stefanovic
%A Rebecca H. Ritchie
%J Archive of "Cardiovascular Diabetology".
%D 2017
%R 10.1186/s12933-017-0513-y
%X Vascular dysfunction is a pivotal event in the development of diabetes-associated vascular disease. Increased inflammation and oxidative stress are major contributors to vascular dysfunction. Nrf2, a master regulator of several anti-oxidant genes and a suppressor of inflammatory NF-¦ĘB, has potential as a target to combat oxidative stress and inflammation. The aim of this study was to investigate the effects of a novel Nrf2 activator, the bardoxolone methyl derivative dh404, on endothelial function in vitro and in vivo
%K Endothelial dysfunction
%K hyperglycemia
%K Nrf2 activators
%K oxidative stress
%K inflammation
%K dh404
%K bardoxolone methyl
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5335831/