%0 Journal Article
%T Advanced glycation end products induce brain-derived neurotrophic factor release from human platelets through the Src-family kinase activation
%A Hidekazu Sotoyama
%A Hirohito Sone
%A Hiroyuki Nawa
%A Ichiro Fuse
%A Kazuo Furukawa
%A Nobuyuki Takei
%A Osamu Hanyu
%A Yuriko Iwakura
%J Archive of "Cardiovascular Diabetology".
%D 2017
%R 10.1186/s12933-017-0505-y
%X Brain-derived neurotrophic factor (BDNF) exerts beneficial effects not only on diabetic neuropathies but also on cardiovascular injury. There is argument regarding the levels of serum BDNF in patients with diabetes mellitus (DM). Because BDNF in peripheral blood is rich in platelets, this may represent dysregulation of BDNF release from platelets. Here we focused on advanced glycation end products (AGEs), which are elevated in patients with DM and have adverse effects on cardiovascular functions. The aim of this study is to elucidate the role of AGEs in the regulation of BDNF release from human platelets
%K AGE
%K BDNF
%K Platelets
%K Release
%K Ca2+
%K Src family kinases
%K Syk
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299653/