%0 Journal Article
%T When fats commit crimes: fatty acid metabolism, cancer stemness and therapeutic resistance
%A Ching-Ying Kuo
%A David K. Ann
%J Archive of "Cancer Communications".
%D 2018
%R 10.1186/s40880-018-0317-9
%X Fatty acid metabolism in cancer. Key enzymes involved in fatty acid (FA) metabolism. Orange-highlighted enzymes have been reported as altered in cancer or associated with cancer stemness. ACC acetyl-CoA carboxylase, ACLY ATP citrate lyase, ACSS2 acyl-CoA synthetase short-chain family member 2, FASN fatty acid synthase, CPT1/2 carnitine/palmitoyl-transferase 1/2, CACT carnitine acylcarnitine translocase, FAO fatty acid oxidation, IDH isocitrate dehydrogenase, TCA cycle tricarboxylic acid cycle, PDK pyruvate dehydrogenase kinase, PDH pyruvate dehydrogenase, P phosphorylation, U ubiquitylation, Ac acetylatio
%K Fatty acid synthesis
%K Fatty acid oxidation
%K Fatty acid metabolism
%K Lipogenic phenotype
%K Cancer stem cells
%K Tumor-initiating cells
%K Cancer cell plasticity
%K Therapeutic resistance
%K Drug-tolerant persisters
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042406/