%0 Journal Article
%T New insights from the widening homogeneity perspective to target intratumor heterogeneity
%A Bin He
%A Mengying Tong
%A Mengying Yang
%A Quentin Liu
%A Wei Cheng
%A Xiaolong Zhang
%A Ziqian Deng
%J Archive of "Cancer Communications".
%D 2018
%R 10.1186/s40880-018-0287-y
%X Current strategies targeting intratumor heterogeneity. Four strategies to solve this problem are as follows. First, targeting a shared pathway. Second, targeting the primary mutation together with the anticipated mutation. Third, finding a target controlling intratumor heterogeneity and plasticity. Fourth, epigenetic therapy that primes cancer to restore sensitivit
%K Acquired drug resistance
%K Homogenization
%K Intratumor heterogeneity
%K Plasticity
%K Precision medicine
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993146/