%0 Journal Article
%T Endothelial Protein C Receptor (EPCR), Protease Activated Receptor-1 (PAR-1) and Their Interplay in Cancer Growth and Metastatic Dissemination
%A Dominika Hempel
%A Ewa Sierko
%A Kenneth V. Honn
%A Marek Z. Wojtukiewicz
%A Stephanie C. Tucker
%J Archive of "Cancers".
%D 2019
%R 10.3390/cancers11010051
%X Endothelial protein C receptor (EPCR) and protease activated receptor 1 (PAR-1) by themselves play important role in cancer growth and dissemination. Moreover, interactions between the two receptors are essential for tumor progression. EPCR is a cell surface transmembrane glycoprotein localized predominantly on endothelial cells (ECs). It is a vital component of the activated protein C (APC)¡ªmediated anticoagulant and cytoprotective signaling cascade. PAR-1, which belongs to a family of G protein¨Ccoupled cell surface receptors, is also widely distributed on endothelial and blood cells, where it plays a critical role in hemostasis. Both EPCR and PAR-1, generally considered coagulation-related receptors, are implicated in carcinogenesis and dissemination of diverse tumor types, and their expression correlates with clinical outcome of cancer patients. Existing data explain some mechanisms by which EPCR/PAR-1 affects cancer growth and metastasis; however, the exact molecular basis of cancer invasion associated with the signaling is still obscure. Here, we discuss the role of EPCR and PAR-1 reciprocal interactions in cancer progression as well as potential therapeutic options targeted specifically to interact with EPCR/PAR-1-induced signaling in cancer patients
%K EPCR
%K APC
%K PAR-1
%K cancer
%K metastasis
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356956/