%0 Journal Article
%T Exploiting poly(I:C) to induce cancer cell apoptosis
%A Andrea Balsari
%A Elda Tagliabue
%A Francesca Bianchi
%A Lucia Sfondrini
%A Samantha Pretto
%J Archive of "Cancer Biology & Therapy".
%D 2017
%R 10.1080/15384047.2017.1373220
%X TLR3 belong to the Toll-like receptors family, it is mainly expressed on immune cells where it senses pathogen-associated molecular patterns and initiates innate immune response. TLR3 agonist poly(I:C) was developed to mimic pathogens infection and boost immune system activation to promote anti-cancer therapy. Accordingly, TLR agonists were included in the National Cancer Institute list of immunotherapeutic agents with the highest potential to cure cancer. Besides well known effects on immune cells, poly(I:C) was also shown, in experimental models, to directly induce apoptosis in cancer cells expressing TLR3
%K C)
%K Toll-like receptor 3 (TLR3)
%K TLR agonist
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678690/