%0 Journal Article
%T BOK promotes chemical-induced hepatocarcinogenesis in mice
%A Andreas Villunger
%A Daniel Bachmann
%A Deborah Stroka
%A Giulio Loforese
%A Matteo Montani
%A Simone Wicki
%A Tatiana Rabachini
%A Thomas Kaufmann
%A Valentina Sladky
%A Yuniel Fernandez-Marrero
%A Zhaoyue He
%J Archive of "Cell Death and Differentiation".
%D 2018
%R 10.1038/s41418-017-0008-0
%X BOK contributes to DEN-induced liver damage. a Bok mRNA expression in the livers of WT and Bok -/- animals after DEN exposure. Hprt served as reference gene. Values represent the mean£¿¡À£¿SD (n£¿=£¿3 mice per group). b Serum ALT levels were determined in WT and Bok -/- mice after DEN exposure (100£¿mg/kg BW). Values represent mean£¿¡À£¿SD. c Representative fluorescence micrographs of TUNEL staining and d quantification of TUNEL-positive cells in livers from WT and Bok -/- animals treated with DEN (100£¿mg/kg BW). Values represent the mean£¿¡À£¿SD (n£¿=£¿3 mice per group). e Quantitative western blot analysis using near-infrared fluorescence of activated caspase-3 in liver lysates from WT and Bok -/- animals 3 days after DEN (100£¿mg/kg) injection. Values represent the mean£¿¡À£¿SD (n£¿=£¿3 mice per group
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864194/