%0 Journal Article %T The tango of ROS and p53 in tissue stem cells %A Changshun Shao %A Keli Liu %A Youguo Chen %A Yufang Shi %J Archive of "Cell Death and Differentiation". %D 2018 %R 10.1038/s41418-018-0062-2 %X ROS and p53 determine the differentiation routes of MSCs. Hyperactivation of p53 drives mitochondrial ROS production and adipocyte differentiation. p53 functions as an antioxidant under physiological condition or mild stress. MSCs are favored to differentiate into osteoblasts when p53 is absent or functionally compromise %U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864234/