%0 Journal Article
%T Targeting the Post-Irradiation Tumor Microenvironment in Glioblastoma via Inhibition of CXCL12
%A Barbara Link
%A Carsten Herskind
%A Frank A. Giordano
%A Frederik Wenz
%A J. Martin Brown
%A Martin Glas
%A Ulrich Herrlinger
%A Viktor Umansky
%J Archive of "Cancers".
%D 2019
%R 10.3390/cancers11030272
%X Radiotherapy is a mainstay in glioblastoma therapy as it not only directly targets tumor cells but also depletes the tumor microvasculature. The resulting intra-tumoral hypoxia initiates a chain of events that ultimately leads to re-vascularization, immunosuppression and, ultimately, tumor-regrowth. The key component of this cascade is overexpression of the CXC-motive chemokine ligand 12 (CXCL12), formerly known as stromal-cell derived factor 1 (SDF-1). We here review the role of CXCL12 in recruitment of pro-vasculogenic and immunosuppressive cells and give an overview on future and current drugs that target this axis
%K glioblastoma
%K radiotherapy
%K CXCL12
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468743/