%0 Journal Article
%T Obesity-Induced TNF¦Á and IL-6 Signaling: The Missing Link between Obesity and Inflammation¡ªDriven Liver and Colorectal Cancers
%A Anna Juliane Vesting
%A Anna Lena Ostermann
%A Claudia Maria Wunderlich
%A F. Thomas Wunderlich
%A Lara Kern
%A Melanie J. Mittenb¨¹hler
%J Archive of "Cancers".
%D 2019
%R 10.3390/cancers11010024
%X Obesity promotes the development of numerous cancers, such as liver and colorectal cancers, which is at least partly due to obesity-induced, chronic, low-grade inflammation. In particular, the recruitment and activation of immune cell subsets in the white adipose tissue systemically increase proinflammatory cytokines, such as tumor necrosis factor ¦Á (TNF¦Á) and interleukin-6 (IL-6). These proinflammatory cytokines not only impair insulin action in metabolic tissues, but also favor cancer development. Here, we review the current state of knowledge on how obesity affects inflammatory TNF¦Á and IL-6 signaling in hepatocellular carcinoma and colorectal cancers
%K Obesity
%K low-grade inflammation
%K liver and colon cancer
%K IL-6 and TNF
%K signaling
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356226/