%0 Journal Article
%T SIRT1 deacetylated and stabilized XRCC1 to promote chemoresistance in lung cancer
%A Hongchuan Jin
%A Hui Chen
%A Jinye Xu
%A Lifeng Feng
%A Neelum Aziz Yousafzai
%A Qiqi Shi
%A Qiyin Zhou
%A Vivian Yvonne Shin
%A Wenxia Xu
%A Xian Wang
%J Archive of "Cell Death & Disease".
%D 2019
%R 10.1038/s41419-019-1592-3
%X a SIRT1 expression in H460-R and H460 lung cancer cells were determined by Western blotting. b Western blot analysis of SIRT1 expression in H460 cells transfected with lentivirus carrying empty vector or SIRT1-expressing vector. c The viability of H460 cells with SIRT1 overexpression after treatment with cisplatin was indicated were measured by MTS assay. d Analysis of apoptosis by Annexin V/propidium Iodide staining with Flow cytometry. Data represents in triplicate and shown as the mean£¿¡À£¿S.D. *p£¿<£¿0.05. e Protein level of cleaved-PARP1, cleaved-Caspase3 and £¿-H2AX in H460 cells after cisplatin treatment were analyzed by Western blottin
%K Cancer
%K Lung cancer
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494911/