%0 Journal Article
%T BRD9 binds cell type-specific chromatin regions regulating leukemic cell survival via STAT5 inhibition
%A Angela Nebbioso
%A Antimo Migliaccio
%A Antonella Di Costanzo
%A Hendrik G. Stunnenberg
%A Joost H. A. Martens
%A Lidio Conte
%A Lucia Altucci
%A Michiel Vermeulen
%A Ning Qing Liu
%A Nunzio Del Gaudio
%J Archive of "Cell Death & Disease".
%D 2019
%R 10.1038/s41419-019-1570-9
%X a Dot plot bioinformatics analysis showing BRD9 expression in publicly available RNA-seq data from 200 primary AML samples, 19 samples of human hematopoietic progenitors, and 16 samples of differentiated human monocyte and macrophage cells. ¦Â-Actin was used as housekeeping gene (P£¿<£¿0.01 Welch¡¯s t-test). b RT-qPCR analysis of BRD9 expression in primary AML samples (pt) compared with CD34+ cells; error bars indicate SD of three biological replicates (*P£¿<£¿0.05, **P£¿¡Ü£¿0.01). c WB analysis of BRD9 in the indicated leukemic cell lines compared with the CD34+. Actin was used as loading control. Error bars indicate SD of three biological replicates (*P£¿<£¿0.05, **P£¿¡Ü£¿0.01
%K Cancer therapy
%K Leukaemia
%K Epigenetics
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472371/