%0 Journal Article
%T Nicotinamide mononucleotide promotes osteogenesis and reduces adipogenesis by regulating mesenchymal stromal cells via the SIRT1 pathway in aged bone marrow
%A Chan Xie
%A Dongjun Lin
%A Fangji Yang
%A Gang Ning
%A Jie Song
%A Jing Li
%A Liang Peng
%A Limin Zhen
%A Lina Wu
%A Qi Zhang
%A Yongyuan Zheng
%J Archive of "Cell Death & Disease".
%D 2019
%R 10.1038/s41419-019-1569-2
%X a Scheme of NMN administration and the CFU-F assay. b Representative images acquired from live cell imaging system showing CFU-F colonies formed by MSCs. c The number of CFU-F contained in MSCs. d Scheme of NMN administration and flow cytometric analysis. e, f The PDGFR¦Á+ MSCs (e), and LepR+ MSCs (f) from enzymatically dissociated femur bone marrow cells are shown. g The frequencies of LepR+ MSCs, PDGFR¦Á+ MSCs, and PDGFR¦Á+ LepR+ MSCs from enzymatically dissociated bone marrow cells. h The cellularity of the enzymatically dissociated bone marrow cells (n£¿=£¿6 mice per group from three independent experiments). *p£¿<£¿0.05, **p£¿<£¿0.01 error bars, s.d
%K Ageing
%K Stem-cell research
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472410/