%0 Journal Article
%T Increased expression of lncRNA CASC9 promotes tumor progression by suppressing autophagy-mediated cell apoptosis via the AKT/mTOR pathway in oral squamous cell carcinoma
%A Dan Chen
%A Huan Liu
%A Kai Yang
%A Yixin Yang
%J Archive of "Cell Death & Disease".
%D 2019
%R 10.1038/s41419-018-1280-8
%X a RT-qPCR results showed that CASC9 expression was significantly increased in OSCC tissues compared with paired adjacent tissues (N£¿=£¿35). b RT-qPCR results showed that CASC9 expression was significantly increased in TSCCA, SCC15 and CAL27 OSCC cells compared to the normal oral mucosal HOMEC cells. c The ISH results showed that the expression level of CASC9 in OSCC tissues was significantly higher compared with the paired adjacent tissues (N£¿=£¿84; scale bars£¿=£¿200£¿¦Ìm). d The mean overall survival time of OSCC patients with a high expression level of CASC9 was significantly lower compared with patients with a low expression level. e IHC analysis showed that the expression of p-AKT was significantly increased in OSCC tissues compared with matched para-carcinoma tissues, and the expression level of LC3 B in OSCC tissues was significantly decreased (N£¿=£¿84; scale bars£¿=£¿200 ¦Ìm). f CASC9 expression levels are positively correlated with p-AKT and negatively correlated with LC3B in OSCC tissues (N£¿=£¿84). All data represent three independent experiments. Data are presented as the mean£¿¡À£¿SD (n£¿¡Ý£¿3). *P£¿<£¿0.05, **P£¿<£¿0.01, ***P£¿<£¿0.001, ****P£¿<£¿0.000
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381212/