%0 Journal Article
%T Tetrandrine enhances the ubiquitination and degradation of Syk through an AhR-c-src-c-Cbl pathway and consequently inhibits osteoclastogenesis and bone destruction in arthritis
%A Changjun Lv
%A Yu Tao
%A Yue Dai
%A Yufeng Xia
%A Yugai Jia
%A Zhifeng Wei
%J Archive of "Cell Death & Disease".
%D 2019
%R 10.1038/s41419-018-1286-2
%X a RAW264.7 cells (up) and BMMs (down) were treated with indicated compounds in the presence or absence of RANKL (100£¿ng/mL) for 5 days. The osteoclasts were stained using a TRAP kit according to the manufacture¡¯s protocol. TRAP-positive multinucleated cells (nuclei£¿¡Ý£¿3) were counted using an inverted microscope. b BMMs were treated with indicated compounds in the presence or absence of RANKL (100£¿ng/mL) for 24£¿h. The cells were harvested and lysed, and the mRNA expressions of TRAP and DC-STAMP were detected by quantitative PCR. The results are representative of three independent experiments. *P£¿<£¿0.05, **P£¿<£¿0.01 vs. indicated grou
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427010/