%0 Journal Article
%T T-type Calcium Channels in Cancer
%A Lauren Antal
%A Miguel Martin-Caraballo
%J Archive of "Cancers".
%D 2019
%R 10.3390/cancers11020134
%X Although voltage-activated Ca2+ channels are a common feature in excitable cells, their expression in cancer tissue is less understood. T-type Ca2+ channels are particularly overexpressed in various cancers. Because of their activation profile at membrane potentials close to rest and the generation of a window current, T-type Ca2+ channels may regulate a variety of Ca2+-dependent cellular processes, including cell proliferation, survival, and differentiation. The expression of T-type Ca2+ channels is of special interest as a target for therapeutic interventions
%K T-type Ca2+ channel
%K cancer
%K proliferation
%K neuroendocrine differentiation
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407089/