%0 Journal Article
%T Genetic variants in the plasminogen activator inhibitor©\1 gene are associated with an increased risk of radiation pneumonitis in lung cancer patients
%A Bo Liu
%A Guangyuan Hu
%A Huihua Xiong
%A Minxiao Yi
%A Qingxu Liu
%A Xianglin Yuan
%A Yang Tang
%J Archive of "Cancer Medicine".
%D 2017
%R 10.1002/cam4.1011
%X Plasminogen activator inhibitor©\1 (PAI©\1) plays a crucial role in the process of lung injury, although its association with radiation pneumonitis (RP) is unclear. We hypothesized that genetic variants in PAI©\1 may influence the risk of RP. In this study, 169 lung cancer patients were genotyped for six single©\nucleotide polymorphisms in PAI©\1 using the Sequenom MassARRAY system. The risk of RP was evaluated by Cox proportional hazards analyses. The cumulative RP probabilities by genotype were assessed using Kaplan¨CMeier analyses. Univariate and multivariate analyses revealed that PAI©\1:rs7242 GT/GG was correlated with an increased occurrence of grade ¡Ý3 RP (crude hazard ratio = 3.331; 95% confidence interval, 1.168¨C9.497; P = 0.024). Our results indicated that PAI©\1:rs7242 in the 3¡ä©\untranslated region of PAI©\1 can be a predictor of grade ¡Ý3 RP before radiotherapy
%K Lung cancer
%K PAI©\1
%K Radiation pneumonitis
%K Radiotherapy
%K Single©\nucleotide polymorphism
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345627/