%0 Journal Article
%T Dipeptidyl peptidase-4 (DPP-4) inhibition with linagliptin reduces western diet-induced myocardial TRAF3IP2 expression, inflammation and fibrosis in female mice
%A Adam Whaley-Connell
%A Annayya R. Aroor
%A Brady Barron
%A Bysani Chandrasekar
%A Dongqing Chen
%A Hemanth Kumar Kandikattu
%A James R. Sowers
%A Jaume Padilla
%A Javad Habibi
%A Melvin R. Hayden
%A Mona Garro-Kacher
%A Shawn B. Bender
%A Thomas Klein
%A Vincent G. DeMarco
%J Archive of "Cardiovascular Diabetology".
%D 2017
%R 10.1186/s12933-017-0544-4
%X Diastolic dysfunction (DD), a hallmark of obesity and primary defect in heart failure with preserved ejection fraction, is a predictor of future cardiovascular events. We previously reported that linagliptin, a dipeptidyl peptidase-4 inhibitor, improved DD in Zucker Obese rats, a genetic model of obesity and hypertension. Here we investigated the cardioprotective effects of linagliptin on development of DD in western diet (WD)-fed mice, a clinically relevant model of overnutrition and activation of the renin-angiotensin-aldosterone system
%K Diastolic dysfunction
%K Myocardial fibrosis
%K Obesity
%K TRAF3IP2
%K Linagliptin
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5420102/