%0 Journal Article
%T Metformin and sulodexide restore cardiac microvascular perfusion capacity in diet-induced obese rats
%A Dennis Koehn
%A Gustav J. Strijkers
%A Hanneke Cobelens
%A Hans Vink
%A Jos Slenter
%A Judith van Haare
%A Jurgen W. G. E. van Teeffelen
%A M. Eline Kooi
%A Marc van Bilsen
%A Mark J. Post
%J Archive of "Cardiovascular Diabetology".
%D 2017
%R 10.1186/s12933-017-0525-7
%X Disturbances in coronary microcirculatory function, such as the endothelial glycocalyx, are early hallmarks in the development of obesity and insulin resistance. Accordingly, in the present study myocardial microcirculatory perfusion during rest and stress was assessed following metformin or sulodexide therapy in a rat model of diet-induced obesity. Additionally, the effect of degradation of the glycocalyx on myocardial perfusion was assessed in chow-fed rats
%K Obesity
%K Endothelial dysfunction
%K Myocardial perfusion
%K Cardiac function
%K Glycocalyx
%K Metformin
%K Sulodexide
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5387275/