%0 Journal Article %T Folic Acid and Homocysteine in Chronic Kidney Disease and Cardiovascular Disease Progression: Which Comes First? %A Antonio De Pascalis %A Chiara Zannini %A Claudio Ronco %A Gaetano La Manna %A Giuseppe Cianciolo %A Luca Di Lullo %J Archive of "Cardiorenal Medicine". %D 2017 %R 10.1159/000471813 %X Hyperhomocysteinemia (Hhcy) occurs in about 85% of chronic kidney disease (CKD) patients because of impaired renal metabolism and reduced renal excretion. Folic acid (FA), the synthetic form of vitamin B9, is critical in the conversion of homocysteine (Hcy) to methionine. If there is not enough intake of FA, there is not enough conversion, and Hcy levels are raised %K Folate pathway %K Homocysteine %K Hyperhomocysteinemia %K Cardiovascular disease %K Chronic kidney disease %U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662962/