%0 Journal Article
%T One-Year Conservative Care Using Sodium Bicarbonate Supplementation Is Associated with a Decrease in Electronegative LDL in Chronic Kidney Disease Patients: A Pilot Study
%A Ana Beatriz Barra
%A Denise Mafra
%A Dulcin¨¦ia Saes Parra Abdalla
%A Felipe Rizzetto
%A Gisella Pires de Melo
%A Maurilo Leite Jr.
%J Archive of "Cardiorenal Medicine".
%D 2017
%R 10.1159/000478733
%X Chronic kidney disease (CKD) patients develop metabolic acidosis when approaching stages 3 and 4, a period in which accelerated atherogenesis may ensue. Studies in vitro show that low pH may increase low-density lipoprotein (LDL) oxidation, suggesting a role for chronic metabolic acidosis in atherosclerosis. The present study attempted to evaluate the effects of conservative care using oral sodium bicarbonate (NaHCO3) supplementation on the electronegative LDL [LDL(£¿)], a minimally oxidized LDL, plasma levels in CKD patients
%K Chronic kidney disease
%K Alkali therapy
%K Electronegative LDL
%K Cardiovascular diseases
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662953/