%0 Journal Article
%T Androgen Receptor: A Complex Therapeutic Target for Breast Cancer
%A James T. Dalton
%A Ramesh Narayanan
%J Archive of "Cancers".
%D 2016
%R 10.3390/cancers8120108
%X Molecular and histopathological profiling have classified breast cancer into multiple sub-types empowering precision treatment. Although estrogen receptor (ER) and human epidermal growth factor receptor (HER2) are the mainstay therapeutic targets in breast cancer, the androgen receptor (AR) is evolving as a molecular target for cancers that have developed resistance to conventional treatments. The high expression of AR in breast cancer and recent discovery and development of new nonsteroidal drugs targeting the AR provide a strong rationale for exploring it again as a therapeutic target in this disease. Ironically, both nonsteroidal agonists and antagonists for the AR are undergoing clinical trials, making AR a complicated target to understand in breast cancer. This review provides a detailed account of AR¡¯s therapeutic role in breast cancer
%K androgen receptor
%K breast cancer
%K selective androgen receptor modulator (SARM)
%K estrogen receptor
%K triple-negative breast cancer (TNBC)
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187506/