%0 Journal Article
%T Novel anticarcinoembryonic antigen antibody¨Cdrug conjugate has antitumor activity in the existence of soluble antigen
%A Daisuke Shinmi
%A Emi Arakawa
%A Junichi Enokizono
%A Junko Iwano
%A Kazuhiro Masuda
%A Kazuma Tomizuka
%A Keisuke Mitamura
%A Minami Suzuki©\Imaizumi
%A Ryosuke Nakano
%A Yasuhisa Shiraishi
%A Yuya Isoda
%J Archive of "Cancer Medicine".
%D 2017
%R 10.1002/cam4.1003
%X Carcinoembryonic antigen (CEA) is a classic tumor©\specific antigen that is overexpressed in several cancers, including gastric cancer. Although some anti©\CEA antibodies have been tested, to the best of our knowledge, there are currently no clinically approved anti©\CEA antibody therapies. Because of this, we have created the novel anti©\CEA antibody, 15©\1©\32, which exhibits stronger binding to membrane©\bound CEA on cancer cells than existing anti©\CEA antibodies. 15©\1©\32 also shows poor affinity for soluble CEA; thus, the binding activity of 15©\1©\32 to membrane©\bound CEA is not influenced by soluble CEA. In addition, we constructed a 15©\1©\32©\monomethyl auristatin E conjugate (15©\1©\32©\vcMMAE) to improve the therapeutic efficacy of 15©\1©\32. 15©\1©\32©\vcMMAE showed enhanced antitumor activity against gastric cancer cell lines. Unlike with existing anti©\CEA antibody therapies, antitumor activity of 15©\1©\32©\vcMMAE was retained in the presence of high concentrations of soluble CEA
%K Antibody
%K antibody¨Cdrug conjugate
%K CEA
%K esophageal cancer
%K gastric cancer
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5387159/